CCASAnet works to understand the HIV epidemic in Latin America and the Caribbean
The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) brings together the expertise and resources of Vanderbilt University Medical Center and clinical and research sites in Argentina, Brazil, Chile, Haiti, Honduras, Mexico, and Peru.
The goal of the CCASAnet project is to create a shared repository of HIV data from Central and South America and the Caribbean, to use the combined data to answer questions about the characteristics of the regional HIV epidemic, and to work together to improve the quality and consistency of clinical research activities at all member sites.
Regional Member of the
International epidemiology Databases to Evaluate AIDS
Recent Publications
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1.
Latin America — Regional profile — 2025 Global AIDS Update — AIDS, Crisis and the Power to Transform | UNAIDS [Internet]. [cited 2026 June 14]. Available from: https://www.unaids.org/en/resources/documents/2025/2025-global-aids-update-latam
1.
Tuberculosis and HIV: Progress towards the 2020 target [Internet]. Geneva: Joint United Nations Programme on HIV/AIDS (UNAIDS); 2019 [cited 2026 May 30]. Available from: https://digitallibrary.un.org/record/3945151
1.
Castillo-Rozas G, Fonseca FF, Castilho J, Rebeiro PF, Machado DM, Luque MT, Jalil EM, Mejia F, Kim A, Shepherd BE, Cortes CP. ART to prevent vertical transmission in Latin America: where are we in the “Treat-All” era? J Int AIDS Soc. 2025 May;28(5):e26411. PMCID: PMC12035647
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